Multiple linear regression analysis was then performed in the whole cohort to assess the individual and combined effect on NTproBNP values of a categorical variable with four levels defined by either individual or combined presence of overweight/obesity and diabetes, independently of other risk factors, obtaining the following results: non diabetes and overweight/obesity, β = −0.12 (p = 0.03); diabetes and normal weight, β = 1.28, (p < 0.0001); diabetes and overweight/obesity β = 1.03 (p < 0.0001). The gene discussed is NPPB; the disease is obesity due to melanocortin 4 receptor deficiency.