In a logistic regression model examining the relationship between overweight/obesity (dependent variable) and quartiles of NTproBNP, independently of diabetes and other confounders, we obtained the following ORs: 0.84 (0.64–1.11), 0.68 (0.50–0.93) and 0.53 (0.37–0.77). Here, NPPB is linked to obesity due to melanocortin 4 receptor deficiency.