Although the clinical impact of the inaccurate BGM systems has yet to be demonstrated in human trials, a recent in silico study of T1DM patients addressed this question in a study that utilized the UVA-PADOVA Type 1 Diabetes Simulator to assess the effect of BGM system accuracy on clinical outcomes.21 In this analysis, we apply findings from the study to assess the financial impact of inaccuracy of BGM devices on changes in HbA1c, annual SHE, and health care resource utilization (insulin and test strip consumption), using the HbA1c Translator model.22 The gene discussed is INS; the disease is diabetes mellitus.