TNF and rheumatoid arthritis: TNF blockade, using anti-TNF antibody-based molecules such as Humira® (adalimumab), Remicade® (infliximab) or Enbrel® (eternacept), is now a widely used approach to treatment for rheumatoid arthritis [17,18,19], and while it is extremely effective in many patients, there are a significant number of non-responders, and symptoms often return after treatment is discontinued.