ATM and familial pancreatic carcinoma: Curcumin, a component of turmeric, derived from the rhizomes of Curcuma longa inhibits proliferation of human pancreatic cancer cells by activation of Ataxia telangiectasia mutated (ATM)/checkpoint kinase 1 (ChK1)/Cdc25C, blocking cyclin B1/Cdk1 activity and arresting cells at G2/M check point [80,81].