The HB3 and CAMP AMA1 antigens show the least sequence identity amongst the four antigens (Fig 4), and the observation of the narrowest limits of agreement between these two antigens variants over most of the sampling time points would suggest two things; i) that parasites circulating in the study area may have AMA1 sequences that differ significantly from these two variants, and ii) that the HB3 and CAMP variants are binding to the fraction of infection-induced antibodies that recognize common, cross-reactive epitopes. The gene discussed is KRT83; the disease is infection.