TBX20 and familial dilated cardiomyopathy: While we found the Tbx20-CASZ1 haploinsufficient mice have evidence of differential regulation in calcium-binding proteins, not surprisingly, the Phospholamban R9C mice have more pervasive effects on calcium-dependent signaling, such as involving ER stress responses, though it is possible that these distinctions may be due to differences in the progression of the fibrosis associated with DCM.