We observed that a subset of the D4476:Bortezomib combinations synergistically inhibited the growth of HCT-116 K-RAS (WT/G13D) and other RAS-mutant cancer cells (SW480, DLD-1, THP-1, HEL, T24, NCI-H1299 and PANC-1) but not HCT-116 K-RAS (WT/−) cells (Figure 6c; Supplementary Figure 6c). Here, KRAS is linked to cancer.