FOXO3 and neoplasm: Importantly, we demonstrated that the half-lives of endogenous FOXO4 as well as FOXO3A are relatively longer in LMB-treated HCT-116 K-RAS (WT/−) cells (Figures 5g and h; Supplementary Figure 5f–g), suggesting that mutant K-RAS is required for the destabilization of multiple FOXO tumour suppressors.