It has been reported that inhibition of NF-κB by overexpressing IκBα-supper repressor (IκBα-SR that completely blocks NF-κB signaling) markedly inhibited TNFα-induced HK2 expression in skeletal muscle cells.28 Here, we found that NF-κB inhibition or YAP knockdown could block TNFα-induced HK2 expression, we wondered whether there is a crosstalk between YAP and NF-κB pathway on the transcriptional regulation of HK2 in breast cancer cells. This evidence concerns the gene HK2 and breast cancer.