IL6ST and colorectal cancer: Adenomatous polyposis coli loss results in the Src family kinase-mediated YAP phosphorylation and activation, which lead to upregulation of the IL-6 signal transducer (IL-6ST/gp130) and tumorigenesis of human colorectal cancer.33 At present, we demonstrate that YAP functions as a sensor for TNFα, and in turn activated YAP and NF-κB synergistically regulate the downstream gene transcription.