Notably, both YAP and HK2 expression were positively correlated with CD68+ stainng in human breast cancer samples (Figure 3i, Spearman’s correlation, r (HK2 vs CD68+)=0.476, P<0.01; r (YAP vs CD68+)=0.526, P<0.01). This evidence concerns the gene HK2 and breast cancer.