YAP1 and neoplasm: For example, hypoxia stimulates YAP though SIAH2-mediated degradation of LATS2.13 Recently, it was reported that intestinal IL-6-gp130 signaling triggers activation of YAP that dependent on Src-mediated phosphorylation to maintain epithelial cell proliferation, providing the evidence that YAP is responsive to the inflammatory microenvironment.14 However, whether YAP also has an essential role in inflammation-associated tumor progression is still largely unknown.