Another interesting case is presented by Arg882His mutation in DNMT3A, a DNAmethyltransferase, which is associated with acute myeloid leukemia, and has beenshown to impair formation of active homotetramers by forming stable inactiveheterodimers that involve one wild-type and one mutated subunit.65 The mutation is annotated as potentialintersubunit contact in our analysis based on a 3D structure of DNMT3A-DNMT3Lcomplex with histone H3 (PDB id 4U7T). Here, DNMT3A is linked to acute myeloid leukemia.