For example, genes associated with neurodevelopmental disorders (ALS2, ATP8A2, FA2H, FGD4, HTRA2, SNAP29, VLDLR, VRK1, WDR81) and rare diseases (ALX1, BBS10, CHST14, DDR2, SLC34A2, TAC3, TACR3) have been identified in Mediterranean and Middle Eastern families. This evidence concerns the gene VLDLR and neurodevelopmental disorder.