For example, genes associated with neurodevelopmental disorders (ALS2, ATP8A2, FA2H, FGD4, HTRA2, SNAP29, VLDLR, VRK1, WDR81) and rare diseases (ALX1, BBS10, CHST14, DDR2, SLC34A2, TAC3, TACR3) have been identified in Mediterranean and Middle Eastern families. The gene discussed is FGD4; the disease is neurodevelopmental disorder.