DYRK1A and Dravet syndrome: Transgenic Dyrk1a mouse models are limited as models of DS because there are multiple genes that are dysregulated in DS, not just Dyrk1a. Consequently, a phenotype that is observed in Dyrk1a transgenic mice may have limited validity as a DS model and may not translate to a trisomic mouse model with many trisomic genes in three copies, due to the lack of interactions with other overexpressed or trisomic genes or differences in developmental trajectories between trisomic mice compared to Dyrk1a transgenic mice.