UCP2 and cancer: In fact, a recent publication of Graier group has demonstrated that cancer cells use the uncoupling proteins 2 and 3 (UCP2/3) to re-establish MICU1 function (and in turn mitochondrial Ca2+ uptake), which is desensitized by methylation mediated by PRMT1 (99), an arginine methyl transferase highly expressed in cancer (100).