In addition, siRNA silencing of IP3R-3 in the colon cancer cell line CACO-2, or non-specific pharmacological inhibition of IP3R by 2APB in gastric cancer cells, induces apoptosis, while over-expression of the receptors protects the cells from apoptosis induced by staurosporine (60). This evidence concerns the gene ITPR3 and malignant colon neoplasm.