Human monoclonal GAD65 Ab b96.11 binds to an epitope that is recognized by anti-GAD65 Ab in T1DM patients [55, 75], whereas human monoclonal anti-GAD65Ab b78 binds to an epitope that is recognized by anti-GAD65 Ab in SPS and CAs [55, 57]. The gene discussed is GAD2; the disease is type 1 diabetes mellitus.