In addition, elevated DNA-“hyper”-methylations for NKG2DLs could be detected in some malignant cells, mainly in acute myeloid leukemia (AML) cells, resulted in a clearance of NKG2DL surface cell expression, also detected for MICA, ULBP1/2 in AML patients (21–23). Here, MICA is linked to acute myeloid leukemia.