Interestingly, there was a noticeable decrease in the phylum Bacteroidetes in newly diagnosed diabetics (39), and in our present study, we observed that patients with detectable IL-8 had T2DM for a longer duration than the NIL8 patients, suggesting that in the early state of diabetes, Bacteroidetes play a minor role in regulating the inflammatory process in diabetes. This evidence concerns the gene CXCL8 and type 2 diabetes mellitus.