Prospective and correlation studies have established an association between the high incidences of chronic inflammatory diseases such as cancer (Il'yasova et al., 2005), diabetes (De Rekeneire et al., 2006), osteoarthritis (Stannus et al., 2013), and cardiovascular disease (Volpato et al., 2001) in aged cohort with increased levels of systemic proinflammatory cytokines such as TNF-α, IL-1β, and IL-6 and acute phase proteins (e.g., C-reactive protein; CRP). Here, CRP is linked to osteoarthritis.