NLRP3 inflammasomes could play a major role in the comorbidity of depression with other systemic diseases, indirectly through an inflammatory response in the brain (Pollak and Yirmiya, 2002; Garg, 2011; Stienstra et al., 2011; Zitvogel et al., 2012; Grant and Dixit, 2013; Lee et al., 2013; Ghisleni, 2017; Kaufmann et al., 2017; Yue et al., 2017). The gene discussed is NLRP3; the disease is major depressive disorder.