TARDBP and amyotrophic lateral sclerosis: The presence of ubiquitinated inclusions containing components of the cytoskeleton, various elements of the protein maintenance machinery, such as TDP-43 and Hsps are characteristic for both familial and sporadic ALS cases (Watanabe et al., 2001; Arai et al., 2006; Neumann et al., 2006; Pokrishevsky et al., 2012).