Importantly, both NG2+ and NG2− engrafted leukemias remained MLLr and mirrored the original pro-B phenotype (CD45+CD19+CD10−) (Figure 2e), with engrafted mice presenting very similar BM and extramedullary hematopoietic site infiltration (Figure 2f), splenomegaly, high WBC counts and a skewed granulocytic-to-lymphoid cell representation in PB (Figure 2g). This evidence concerns the gene PTPRC and leukemia.