This was consistent with the literature about effects of obesity on these peptides and was not present in two infants with PWS prior to hyperphagia and obesity onset (unpublished data reported in [64]), suggesting that NPY/AGRP neurons function appropriately in PWS, and any deviance from normative levels can be accounted for by factors such as obesity. The gene discussed is AGRP; the disease is Prader-Willi syndrome.