Finally, Pasi et al., (1989) [69] reported no clear alterations of beta-endorphin levels pertaining to PWS in a single case post-mortem study of a young female adult with PWS, despite literature suggesting an association between beta-endorphin increases in CSF and appetite, pain insensitivity and thermoregulation difficulties [69]. This evidence concerns the gene POMC and Prader-Willi syndrome.