The role of EMT master genes, in particular Snail, in tumor progression was found to be mediated by (i) the direct transcriptional repression of an extensive amount of target genes involved both in epithelial (e.g., E-cadherin) [22] and hepatic (e.g., HNF4α) [23] differentiation, (ii) the increase of mesenchymal gene expression [23], and iii) the miRNA-mediated up-regulation of stemness genes [24]. Here, HNF4A is linked to neoplasm.