French et al used immunohistochemistry and found moderate to increased staining for FGFR4 for 33% of HCCs and confirmed this finding in a small number of 23 samples with qualitative real-time polymerase chain reaction (q RT-PCR) where FGFR4 expression was more than 2-fold higher in 30% of the tumours [36]. Here, FGFR4 is linked to neoplasm.