The same group also reported an interesting association between a specific single nucleotide polymorphism (SNP) of FGFR4 (G388R) and alpha fetoprotein (AFP) which is an established clinical biomarker of tumour progression; using cell lines they proved that there is a direct link between them since stimulation of FGF19 results in elevation of AFP whilst silencing of FGFR4 results in reduced AFP production [37]. This evidence concerns the gene FGFR4 and neoplasm.