Most notably, DR3 has been shown to have a role in several autoimmune diseases, including rheumatoid arthritis (RA) [5], [6], [7], [8], [9], [10] and inflammatory bowel disease (IBD) [11], [12], [13], [14], [15], [16], [17], both of which are considered chronic in nature. This evidence concerns the gene TNFRSF25 and rheumatoid arthritis.