CXCL2 and inflammatory response: Despite the broad range of cell types affected, the decrease in DR3ko cell numbers following acute OVA challenge was not due to defective chemokine production as seen in acute peritoneal inflammation [37], as no disparities were seen in CCL3, CCL4, CCL5, CXCL1, CXCL2, CXCL10 or CXCL13 levels in the BALF following the induction of lung inflammation (Table 1).