The structures of three independent complexes (eIF6-SBDS, eIF6-SBDS-EFL1, and SBDS-EFL1 bound to the 60S subunit) were determined, revealing that the SBDS protein binds to the ribosomal P-site on the intersubunit face of the 60S subunit (Fig. 3A and B) in close proximity to a conserved essential internal loop of ribosomal protein uL16 that is targeted by mutations in paediatric T-cell acute lymphoblastic leukaemia (T-ALL) (De Keersmaecker et al., 2013). The gene discussed is EFL1; the disease is T-cell acute lymphoblastic leukemia.