LSS and hepatocellular carcinoma: Additionally, increased expression levels of enzymes such as Acacb, Acsl, Fasn, Lss, Dhcr7, Mvd, and Fntb stimulated lipid synthesis and the accumulation of lipids to form large quantities of lipid droplets in HCC cells (Fig. 4A; Tables 1, 2; Fig. 1B, D).