VEGFA and neuroblastoma: Results in human neuroblastoma cells have demonstrated that the HBS in the VEGF promoter is demethylated after 24 hrs of hypoxia and that VEGF mRNA increases at 16 hrs of hypoxia strictly dependent on the enzymes involved in CpG demethylation 50 supporting the hypothesis that during the hypoxic response, a rapid CpG demethylation occurs at the HBS and that there is a tight correlation between hypoxia‐induced CpG demethylation and VEGF transactivation.