Finally, the methylation of CpG sites in the VEGF gene promoter results in reduced HIF‐1‐driven VEGF expression in the human placenta after preeclampsia and in tongue carcinoma cells in response to hypoxia 28, 29, thus suggesting that something similar might occur in in vivo models of hypoxia‐driven neovascular diseases of the retina. This evidence concerns the gene VEGFA and preeclampsia.