In consideration of structural similarity between SPOCK1 and SPARC, it is interesting to note that SPOCK1 plays a crucial role in cancer cell invasion in oesophageal squamous cell carcinoma 11, colorectal cancer 12 and gallbladder cancer 13, which indicates that SPOCK1 may be a novel gene of interest, involved in the invasion and metastasis of cancer cells. This evidence concerns the gene SPARC and cancer.