IL4 and immune system disorder: Allergic rhinitis is an immune disorder, and it is caused by hypersensitivity towards all kinds of allergens.1, 7 Recent studies have suggested that T helper type 2 (Th2) cells and mast cells play crucial roles in the pathogenesis and process of allergic reactions during AR.8 T helper type 2 cells mediate the activation and maintenance of the allergens and secrete a population of Th2 cytokines, such as interleukin 4 (IL‐4).