Building on our initial observations showing that a co-ultramicronized composite of the fatty acid amide PEA and the flavonoid luteolin promotes the morphological and molecular maturation of differentiating OPCs64 and improves the clinical score in myelin oligodendrocyte glycoprotein (MOG35-55)-induced experimental autoimmune encephalomyelitis in female C57BL/6 mice (a model often used as a chronic first-pass model of MS)63, we now demonstrate that co-ultraPEALut significantly limits the rise in Saa1 gene expression in OPCs subjected to a 1-week exposure to TNF-α. The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.