One of the important mechanisms that underlie anticancer drug resistance is the high level and capacity of antioxidants in cancer cells10, which are primarily regulated by the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and kelch-like ECH-associated protein-1 (KEAP1) signaling pathway, one of the most important cell defense and survival pathways11. This evidence concerns the gene NFE2L2 and cancer.