For instance, linc00460expression was significantly lower in Neural tube defect patient than normal(GDS2470) (Supplementary Figure S3A); linc00460 expression was decreased whenknockdown LSD1 in neuroblastoma cell lines (GDS5281) (Supplementary Figure S3B);MTX-sensitive HT29 colon adenocarcinoma cell line presented higher linc00460expression than MTX-resistant HT29 colon adenocarcinoma cell line (GDS3330)(Supplementary Figure S3C). This evidence concerns the gene LINC00460 and neuroblastoma.