In conclusion, we identified a novel lncRNA named linc00460, which acted as oncogenein ESCC; CBP/P300 up-regulated linc00460 expression through binding to linc00460promoter and modulating chromatin architecture; linc00460 could be a candidatebiomarker for ESCC diagnosis and treatment. This evidence concerns the gene CREBBP and esophageal squamous cell carcinoma.