It has been reported that HOTAIR wasoverexpressed in breast cancer partly because of the binding of the CBP/P300 to thepromoter of HOTAIR [48]; also, it has beenreported that CREB unregulated the expression of lncRNA HULC through binding to thecore promoter of this lncRNA [49], whereasCBP/P300 can interact with CREB directly. This evidence concerns the gene EP300 and breast cancer.