Overall the frequency of mutations observed in the hallmark genes were consistent with COSMIC and TCGA HNSCC data with altered frequency for TP53 and NOTCH1, but consistent with reports from ICGC-India (Gingivo-buccal) [28], tongue subsite from India and Asia [29], [30] (Supplementary Table S6). The gene discussed is NOTCH1; the disease is head and neck squamous cell carcinoma.