Recently, Kuroda et al. [13] reported that cisplatin resistance was associated with heme oxygenase (HO)-1 in lung cancer cells through EGFR-mediated PI3K/Akt and NF-κB pathways, which is restored by EGFR-selective tyrosine kinase or Akt inhibitor. The gene discussed is AKT1; the disease is lung carcinoma.