Besides, Increased MUC5AC was found to be positively associated with tumor size, pN stage, Fuhrman grade, LVI, rahbdoid differentiation, sarcomatoid features, tumor necrosis, ECOG-PS and recurrence, which might be conducive to better understand the pathogenesis of ccRCC, even found a way to targeted therapy (Table 1). Here, MUC5AC is linked to nonpapillary renal cell carcinoma.