MUC5AC and nonpapillary renal cell carcinoma: As shown in Figure 2, ccRCC patients with high MUC5AC expression had a poorer OS comparing with those with a low MUC5AC expression in the overall cohort of patients with TNM stage III + IV (hazard ratio (HR), 7.620; 95% confidence interval (CI), 4.112 – 14.120; P < 0.001; Figure 2C).