To address this issue, we conducted a meta-analysis of randomized clinical trials (RCTs) to determine the efficacy and safety of PD-1 or PD-L1 antibodies compared with standard second-line therapy docetaxel alone and to assess the possible association between the level of PD-L1 and the prognosis of PD-1/PD-L1 antibodies in patients of advanced NSCLC. Here, CD274 is linked to non-small cell lung carcinoma.