HOTTIP and neoplasm: In addition, we found that high HOTTIP expression was positively associated with poor tumor differentiation (OR = 1.55, 95% CI: 1.03–2.32, P = 0.036) and a poor clinical stage (OR = 3.28, 95% CI: 2.22–4.83, P < 0.001) (Figure 4, Table 2).