For the last 5 years, many reports have revealed that decreased TUSC7 expression is correlated with unfavorable overall survival (OS) in various tumors, including non-small-cell lung cancer (NSCLC) [7], colorectal cancer (CRC) [13, 14], esophageal squamous cell carcinoma (ESCC) [15], osteosarcoma (OSA) [16] and so on. Here, TUSC7 is linked to esophageal squamous cell carcinoma.