HOTAIR and colorectal carcinoma: Recent findings have suggested that many lncRNAs have important biological roles in CRC, such as CASC2 [25], UCA1 [26], CCAT2 [27] and HOTAIR [28] et al. Our previous work also identified that lncRNA Loc554202 induces CRC cell apoptosis through the activation of specific caspase cleavage cascades [29].