We previously found that HOTTIP promotes CRC cell proliferation partly via down-regualtion of p21 expression, while IRAIN could promote pancreatic cancer cell growth by binding to histone demethylase lysine-specific demethylase 1 (LSD1) and enhancer of zeste homolog 2 (EZH2) [12, 13]. Here, EZH2 is linked to familial pancreatic carcinoma.