The minor allele “A” of rs12580300 in SH2B3 was associated with CAD risk in the female population under the codominant (p = 0.043), dominant (AA + AG vs. GG: OR = 0.59, 95% CI: 0.35-0.97; p = 0.039), and additive (OR = 0.63, 95% CI: 0.44-0.91; p = 0.012) models. This evidence concerns the gene SH2B3 and coronary artery disorder.