Interestingly, in our recent study using an Amyotrophic Lateral Sclerosis (ALS) mouse model, σ1-R in motoneuron subsurface ER cisternae was found in juxtaposition with Kv2.1 in the plasma membrane, implicating possible σ1-R regulation of Kv2.1 activity through direct or indirect interactions [25]. This evidence concerns the gene KCNB1 and amyotrophic lateral sclerosis.