In general, we did not observe statistically significant association between LEP G2548A polymorphism and BC risk under the genetic models of AA versus GG, GA versus GG, AA+GA versus GG, AA versus GA+GG and G-allele versus A-allele (OR = 1.105 with 95 % CI 0.699-1.749, OR = 0.991 with 95 % CI 0.857-1.147, OR = 1.081 with 95 % CI 0.942-1.241, OR = 1.074 with 95 % CI 0.692-1.668 and OR = 1.02 with 95 % CI 0.792-1.134, respectively). The gene discussed is LEP; the disease is breast cancer.