LEPR and breast cancer: However, in the subgroup analysis by ethnicity, we found LEPR Q223R polymorphism was associated with a decreased risk of BC among Asians under the five genetic models: G versus A (OR = 0.532, 95% CI = 0.311-0.856, P = 0.009), GG versus AA (OR = 0.233, 95% CI = 0.092–0.59, P = 0.002), GA versus AA (OR = 0.294, 95% CI = 0.124–0.699, P = 0.006), GG versus AA+AG (OR = 0.635, 95% CI = 0.521–0.787, P < 0.001) and GA+GG versus AA (OR = 0.242, 95% CI = 0.097–0.607, P = 0.003), while no meaningful correlation was observed in Caucasians.