SPON2 and colonic neoplasm: Another study showed that SPON2 is a transcriptional target of the metastasis gene MACC1, ectopic SPON2 expression promoted cell motility and proliferation in colorectal cancer cell cultures, metastasis formation was found in mice xenografted with colon cancer, and metastasis-free survival of colorectal cancer patients with low SPON2 expression in vitro [9, 10].