In both lung cancer cell lines A549 and H838, Liu et al. demonstrated a significant decrease in DNMT1 mRNA and protein expression levels by 5-Aza-CdR, which resulted in demethylation of RASSF1A in A549 but of RASSF1A, ASC, and APC in H838 [28]. This evidence concerns the gene RASSF1 and lung cancer.