PATZ1 and cancer: Since PATZ1 loss/downregulation has been associated with the acquisition of a mesenchymal phenotype in cancer cells [20], and the mesenchymal phenotype in GBMs is associated with the poorest prognosis and most aggressive phenotype, with advantage in proliferative capacity and neovascularization [5, 38], we speculate that a subset of proneural GBMs may be more aggressive due to the downregulation of PATZ1 and consequent activation of a mesenchymal program.