MGMT and glioblastoma: Then, extending the analysis to the TCGA dataset, including samples subclassified in the four subtypes described by Verhaak et al. [7], the capacity of PATZ1 to discriminate GBM patients with different prognosis was significantly shown also in the proneural subtype, where low levels of PATZ1 correlate with worse outcome in both overall and progression-free survival curves, independently from other known prognostic factors, such as MGMT promoter methylation and age at diagnosis.