Moreover, we showed that PATZ1 is expressed in GSCs both in vitro (in GBM-derived stem cells) and in vivo (human tissue specimens), is downregulated in differentiated cells from the same tumor as compared to GSCs, and its expression is higher in GSCs growing as spheres (likely proneural) than in GSCs growing as adherent cells (likely mesenchymal). This evidence concerns the gene PATZ1 and glioblastoma.