CXCR4 and glioblastoma: Indeed, we found that CXCR4 was a high significant prognostic and predictive factor in proneural GBM, were high CXCR4 patients show worse outcome considering both OS and PFS survival curves (Figure 7A–7B), and negatively correlated with PATZ1 in these patients (r = -0.449; p = 0.03) (Figure 7C).