Consistently, by studying the gene signature correlated with the expression of PATZ1 in the context of GBM, we found that PATZ1 expression positively associates with proneural genes, including SOX2, OLIG2, DLL3, NOTCH1, PDGFRα and many others, while negatively associates with the mesenchymal marker CD44 and many other genes characterizing the mesenchymal signature (Table 2 and Supplementary Table 3). The gene discussed is CD44; the disease is glioblastoma.