Other serum-based models, such as AST to alanine aminotransferase (ALT) ratio (AAR), red cell distribution width (RDW) to PLT ratio (RPR) have also been reported to predict significant liver fibrosis and cirrhosis over the past decade in CHB patients, but they are somewhat difficult to use in clinical practice to perform the satisfactory outcomes [19–21]. This evidence concerns the gene GPT and Cirrhosis.