TF and neoplasm: Depletion of TF in MDA-MB-231-Luc (Figure 5A, 5B), HCC1806-Luc (Supplementary Figure 3A, 3B) and BxPC3-Luc (Supplementary Figure 3C, 3D) cells all resulted in a profound inhibition in lung invasion as assessed by bioluminescence imaging at 4 h following tail-vein injection of tumor cells.