TF and neoplasm: TF/FVIIa complex also binds and stimulates protease activated receptor 2 (PAR2)-mediated intracellular signaling pathway and activates ERK/MAPK and PI3K pathways, which positively regulates integrin signal, production of chemokines, proangiogenic factors and matrix metalloproteinases thereby facilitating inflammation, angiogenesis and tumor growth [10, 11].