IRAK4 and neoplasm: Similar gene expression analyses performed for the NF-κB pathway demonstrated increased expression of NF-κB-associated genes (Ccl2, Vcam1, Bcl2l1, Cxcl2, and Icam1) and a downregulation of NF-κB anti-tumor genes (Irak4, Tlr4, Ly96, and Lta) in R7 BCSCs compared to R7shRon BCSCs (Figure 5C and Supplementary Table 6), validating that HGFL-RON signaling BCSCs have higher NF-κB signaling.