In addition to changes in cell-intrinsic mechanisms, HGFL-RON signaling in BCSCs also induced the transcription of genes that stimulate the metabolism of steroids as well as activities in the tumor microenvironment (TME), such as angiogenesis, extracellular matrix organization, and wound response, all of which promote tumor progression and recurrence [16, 21, 45]. This evidence concerns the gene MST1R and neoplasm.