In conclusion, we have shown that the stimulation of HCC cells with the urushiol derivative DC induces p62 transcription through the IRE1α/JNK/c-jun pathway involving a rise in cytosolic Ca2+ and autophagosome formation through the mTOR/ULK1 signaling pathway, thereby promoting cell death (Figure 7). Here, SQSTM1 is linked to hepatocellular carcinoma.