CASP8 and malignant colon neoplasm: Recently, Panaretakis found that anthracycline drugs mitoxantrone and oxaliplatin can stimulate ER stress in colon cancer cell line CT26, activate the phosphorylation kinase of ER elF2α, resulting in the phosphorylation of elF2α and structural changes of caspase-8, apoptosis regulators BAX and Bak.