Further, we also compared the autoantibody signatures with the serum proteomic profiles of patients and came across similar trends in IGHG4 levels; autoantibodies to IGHG4 were highly downregulated in meningioma patients and the levels of the IGHG4 protein was also found to be lower in comparison to unaffected healthy individuals (Supplementary Table 4). This evidence concerns the gene IGHG4 and meningioma.