Moreover, by employing AKT and p42/44 MAPK phosphorylation studies we found that S1P, C1P, LPA, and LPC activate phosphorylation of p42/44 MAPK in the NSCLC cell line A549 and in the SCLC cell line CRL5853 (Figure 2). Here, AKT1 is linked to non-small cell lung carcinoma.